"Drugs per se are no threat to a patient. A physician’s ignorance either through lack of knowledge of interaction or through lack of adequate observation of the patient and proper interpretation of new events is dangerous."
Kenneth Lloyd Melmon, 1978

"He is the best physician who knows the worthlessness of most medicines."
Benjamin Franklin

The editors of this first edition of 25 Landmark Trials in Cardiology are to be commended for their efforts. They bring together practical, up-to-date reviews of the major clinical trials that have had such a positive impact on patient survival and length of life. David Sackett describes evidence-based medicine as "the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients" (BMJ 13 Jan 1996). All that separates us from quackery is the judicious use of scientific evidence. This book provides that evidence.
Peter Hamilton, BSc,MBBCh,FRCPC(C), Internal Medicine Program Director, University of Alberta

About the authors

Dr. Gabor Gyenes received his Medical Doctorate at Semmelweis University, Budapest in 1984. Currently, he is Assistant Professor and Staff Cardiologist at University of Alberta. He is involved in several international multicenter trials. He wrote a handbook on Hypertension in 1997, another on Coronary Angiography and Angioplasty in 2001 and co-edited a textbook in Cardiology in 2000. He defended his PhD thesis in 1997 at the Karolinska Institute in Stockholm, Sweden. He has over 40 peer-reviewed publications and was awarded “Eminent Scientist of the Year 1999” by the International Research Promotion Council.

Dr. Craig Butler is an internist registered with the Royal College of Physicians and Surgeons of Canada and is currently in the final year of Cardiology residency training at the University of Alberta. He has completed a Masters in Epidemiology, also from the University of Alberta, Department of Public Health Sciences. Dr. Butler’s current research interests lie in the area of non-invasive imaging with particular emphasis on Cardiac Magnetic Resonance and CT angiography.